DIAMONDS is a Generic Data Management and Data Integration Platform for the Life Sciences developed by TNO. DIAMONDS, has a broad scope and is used by many and very diverse Life Science projects. From estimating the Toxicity of Compounds, Safety Assessment of Targets, Allergenicity of Proteins up to Modelling Health parameters and providing Personalized Nutritional and Lifestyle Advice.

DIAMONDS brings together Data, Knowledge and Algorithms. Data ranges from Clinical studies and Omics data to Personalized Health data. Traceable from original Raw measurements to Cleaned, Processed data ready to use. Knowledge ranges from Biological Knowledge from Curated databases and Textmining to manually Curated Triples from our Experts. All captured and connected to Source information through Standardized Pipelines and Workflows Protocols. Diverse tools and algorithms such as Statistical tools, Text mining methods, Scripts, Decision Trees, Bayesian/Dynamic Networks and Network Visualization.

DTOX is a DIAMONDS project that integrates knowledge and data relating to the chemical structure, kinetics, metabolism, system biology and toxicity of substances with Omics data obtained from alternative experimental models for biological verification. This enables faster, more informed choices when investigating the safety of chemical substances for product development and/or registration.

The current risk-assessment method for chemical substances requires a great deal of research. This can be done more quickly and effectively by combining areas of expertise and available data. For this purpose, TNO uses the DIAMONDS approach, a ‘new-style’ toxicological risk assessment method that makes it possible to determine the toxic properties of a chemical substance at an early stage, thereby reducing costs and preventing unnecessary testing on animals.

TargetTri is an online platform for profiling drug targets in terms of safety and efficacy. TargetTri integrates text-mining, data-mining and network biology to obtain a complete view on effects exerted by target modulation. Queries can be initiated from either a protein/gene or a therapeutic indication.

At TNO, we know drug targets and we can help you assess your target in an early phase of drug development. By combining our diverse capabilities, we offer services that extract, integrate and interpret data regarding your target and translate this into valuable information for decision making. With a track record in target safety assessment for many years, we do offer additional services in the area of efficacy assessment and biomarker identification. In addition, we offer tailor-made solutions and are developing the target intelligence platform TargetTri together with the pharmaceutical industry to be used as an in-house tool for more efficient target assessments.

Psycat is a DIAMONDS project that provides a valid instrument designed to detect psychosocial problems in children. It is an intelligent web-based questionnaire that smartly decides which questions to ask based on the given answers so far. Psycat is available for parents of children in the ranges of 2 to 4 and 7 to 11 years.

Psycat is an efficient and reliable alternative for existing instruments for detecting psychosocial disorders in children. When compared to existing questionnaires, e.g. the Strengths and Difficulties Questionnaire (SDQ), Psycat offers the following advantages: It gives reliable and valid information about the nature of the mental problem, Psycat is a fast and adaptive instrument, It provides easy readable graphic results.

ECEL 3.0 is a public tool developed on the DIAMONDS platform that offers a searchable library of occupational and environmental Risk Management Measures (RMM). Supporting registrants to evaluate the quantitative effectiveness of a specific RMM or downstream users (industry, research, consulting) on the most suitable RMM for a given exposure or emission scenario.

TNO and CEFIC have developed an integrated Risk Management Measure library (ECEL v3.0) as part of the CEFIC LRI B15 project. ECEL v3.0 offers a comprehensive source of information on RMMs and applies a statistical method to derive and visualize effectiveness values for both occupational and environmental RMM scenarios.

This tool is available free of charge. Please register or log in below and get direct access to ECEL3.0

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The LICARA Innovation Scan is a public tool that allows a preliminary but swift assessment of benefits and risks for innovative products.

The LICARA Innovation Scan is based on the LICARA nanoSCAN previously developed by TNO and EMPA, focusing on the evaluation of innovative nanoproducts. In the Perocube project, TNO has extended the application of the scan to all innovative products including, but no longer exclusively, nano products.

Both tools are available free of charge, please register or log in below and get direct access to the new version of the LICARA nanoSCAN and/or the new LICARA Innovation Scan.

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